$117.95★ Add to wishlist
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition reflects significant changes in the process of drug design over the last decade. It preserves the successful approach of the previous editions while including significant changes in format and coverage. New to this edition: * Updates to all chapters, including new examples and references* Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book* Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry* Chapter 3 (Receptors): Drug-receptor interactions, cation-? and halogen bonding; atropisomers; case history of the insomnia drug suvorexant* Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis* Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: * for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib* for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid* for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin* Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples* Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites* Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody-drug conjugates
Domestic freight is via Australia Post. Alternatively we have a 'Click & Collect' option at no cost where the order can be picked up from the CDU Bookshop.
|Orders||Parcel Post||Express Post|
|5kg to 8kg||$40.00|
|8kg to 10kg||$45.00|
CDU Bookshop will not be responsible for late orders due to incorrect postal address.
Please note: Darwin is outside the next day delivery service guarantee for Australia Post. Express bags to capital cities can take up to seven working days.
We will despatch books within 24 hours of order however, if the complete order is not in stock we will do our best to contact customers and arrange split deliveries which may incur additional freight charges.*The weight of each book can be found in the tags below
A refund of money will only be provided where books or other items purchased are: defective or faulty OR fail to match the description.Credit Notes will be considered under the following circumstances:
Symptoms in the Pharmacy is the indispensable guide to the management of common symptoms seen...
This book clearly presents the basic concepts of pharmacokinetics through graphs and simulations. Expanding on...
Informed by the experiences and expertise of seasoned pharmacists and GPs, this reference guide provides...