An independent, evidence-based, national drug reference, the Australian Medicines Handbook is an important clinical resource for health practitioners concerned with the quality use of medicines. The comparative drug information makes it unique among drug reference tools on the market, as it allows users to compare drugs and make informed prescribing choices. 

Therapeutic information documents clearly summarise evidence and clinical practice for some diseases to give context for drug treatment.
Class statements provide common and comparative information on drugs of the same class or family. 
Substantial drug interactions section contains useful advice for clinicians on managing specific interactions. 
Individual drug monographs with succinct descriptions of mode of action, indications and precautions, adverse effects, brand names and products, PBS information and off-label uses, patient counselling and practice points, among other things.